EquiCore™ MOTS-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

Molecular Formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

MOTS-c is a naturally occurring mitochondrial-derived peptide (MDP) composed of 16 amino acids, encoded within mitochondrial DNA. It plays a key role in regulating cellular metabolism, insulin sensitivity, and energy homeostasis, making it a unique signaling molecule linking mitochondrial function to whole-body metabolic health.

Product Overview

MOTS-c is recognized for its ability to optimize metabolic function and enhance cellular resilience, particularly under conditions of stress or aging. By influencing key metabolic pathways, it supports improved energy utilization, glucose regulation, and fat metabolism—making it a valuable peptide for performance, recovery, and longevity-focused applications.

Key Benefits

1. Metabolic Optimization

• Enhances glucose utilization and metabolic efficiency

• Supports improved insulin sensitivity

• Helps regulate energy balance at the cellular level

1. Fat Loss & Body Composition

• Promotes fat oxidation and utilization

• Supports reduction in adipose tissue

• Encourages lean body composition

1. Mitochondrial Function & Energy Production

• Supports mitochondrial health and biogenesis

• Enhances cellular energy output (ATP production)

• Improves overall metabolic flexibility

1. Exercise Performance & Endurance

• Mimics some effects of exercise at the cellular level

• Enhances endurance and physical performance

• Supports faster adaptation to training stress

1. Cellular Stress Resistance

• Activates pathways involved in cellular protection and survival

• Helps cells adapt to metabolic and oxidative stress

• Supports long-term cellular resilience

1. Longevity & Healthy Aging Support

• Associated with improved metabolic health markers

• Supports pathways linked to aging and lifespan regulation

• Helps counteract age-related metabolic decline

Mechanism of Action

MOTS-c acts as a metabolic regulator by influencing nuclear gene expression and activating key pathways such as AMPK (AMP-activated protein kinase). This leads to improved glucose uptake, enhanced fat metabolism, and increased cellular energy efficiency. It also facilitates communication between mitochondria and the nucleus, helping coordinate adaptive responses to metabolic stress.